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BRCA2— Is It Better Not To Know?

June 17th, 2013 |
Awareness & Education, Recently Diagnosed

by MightyMelanie | Survivor: Breast Cancer    Connect


When Melanie's doctors suggested that she should undergo genetic testing after being diagnosed with breast cancer, she didn't think twice. That's when she learned about one of the many traits she shared with her father: the BRCA2 gene.

My Father died on November 2, 2009 after facing down prostate cancer and then renal failure. Sadly, I was not at his side when he passed away peacefully in his sleep before dawn. I had just completed my second breast cancer surgery within six weeks and was still in New York with a drain attached to the left side of my body.

I adored my father.

We had a dual relationship: father-daughter and business advisor-business woman. Way too frequently the two relationships collided. One minute we would discuss a tax issue, payroll or another business matter; the next he would share gossip from my hometown Chattanooga, tell me a joke or read me a chapter of the latest book he was writing about the Civil War. We'd fight over business and then share funny stories. He stood up for me when the banks turned me down for my first business loan and stood by me when my heart was crushed over a passing love affair.

We were both alike in so many ways. I inherited his business sense and his work ethic. I also inherited his sensitive skin, his square shoulders and his mischievous grin (or so people tell me). We shared a love for great wines, far flung travel and the brilliant ray of light who is my mother, whom he called Sunny. We also shared a "cancer gene" mutation called BRCA2. There is also a BRCA1 gene - they both translate to cancer but with different mutations and associated cancer risks. After I was diagnosed with breast cancer, I realized I didn't know much about my family's health history- who thinks about these things? Thankfully, my mother seemed to know everything about everyone in my family.

My father had prostate cancer and a bout with melanoma, and after I researched the family tree, I found out that his mother had pancreatic cancer, as did my paternal great grandmother. These cancers can also share the BRAC2 gene. Also, 1 out of 40 individuals with a background from the Ashkenazi Jewish population has inherited one of three founder mutations in BRCA1 and BRCA2. (According to "Clinical Genetics Service Follow Up Report" from Memorial Sloan Kettering Hospital).

My doctors suggested that I undergo genetic testing.

I did not give it a second thought. It wasn't like I was at risk for getting cancer. I already had cancer. I just didn't understand "why me?" when no one else in my immediate family had breast cancer. I assumed the cancer was the result of too much stress and being a bit overweight, but I knew that learning whether or not there may have been a genetic influence would explain more.

The test is simple. A nurse practitioner pricks your finger, and your blood is tested. First you fill out a zillion more forms, and counselors sit down and talk you through everything. It is all very thorough and not intimidating.

Testing positive for the BRCA2 gene meant that I had a 27% chance of getting ovarian cancer by the time I hit age 70. So I decided to have my ovaries and Fallopian tubes removed, a prophylactic surgery called an "oophorectomy." The name sounds like the way you feel post-surgery - "Oooph!" If my cancer had only been in one breast, the risk of a recurrence in the second breast could be as high as 25-30% barring various factors. For me that was a non-issue; both my breasts had cancer and needed to go.

Some people may be afraid of undergoing genetic testing, especially if you have not been diagnosed with any of these cancers, are of child bearing age or have children. To that fear I ask, is not knowing better or worse? For some, knowing puts a cloud of fear in their minds. And how will it impact their children? Could it affect their health insurance? The specter of getting cancer puts the fear in everyone; the reality of having it puts you in survivor mode and teaches you to face your worst fear head on.

If I have to choose a fear of the unknown or a fear of knowing the truth, I prefer the latter. The glass is still half full even if there is a dash of BRCA2 in it. If you still are not sure, speak to your doctors and seek out others who have undergone genetic testing. You have my opinion. I got it off my chest!

My father died before knowing that I had the gene, our special bond. I am glad he never knew; it would have made him sad although it also would have brought us even closer. We shared the same spirit and the same courage to face anything that comes our way with a certain inner strength and sense of humor.

If my father were alive today he would tell me, "I am proud of you Melanie. You did the right thing. We will face it together."

In many ways we did.


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Melanie Young-Ransom is a breast cancer survivor and the author of "Getting Things Off My Chest, A Survivor’s Guide To Being Fearless and Fabulous in the Face of Breast Cancer" You can visit her blog at here and find her on IHadCancer under the username MightyMelanie.

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